
Description
TNF-α, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein. It can cause cytolysis of certain tumor cell lines; it is involved in the induction of cachexia; it is a potent pyrogen, causing fever by direct action or by stimulation of interlerukin-1 secretion; it can stimulate cell proliferation and induce cell differentiation under certain conditions. .
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