Description
SUMO1 activating enzyme subunit 1 (SAE1) Homo sapiens Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al. 1999 [PubMed 9920803]). [supplied by OMIM, Mar 2010],
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