Description
Disease: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign. function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the Ro 60 kDa family. similarity: Contains 1 TROVE domain. subunit: Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
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