Description
Caution: It is uncertain whether Met-1 or Met-43 is the initiator. Domain: The DEP domain is involved in membrane localization independent from regulation by cAMP. function: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. similarity: Contains 1 cyclic nucleotide-binding domain. similarity: Contains 1 DEP domain. similarity: Contains 1 N-terminal Ras-GEF domain. similarity: Contains 1 Ras-GEF domain. tissue specificity: Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
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